After hitting the ceiling on my 256 GB SSD, I deleted around 20 GB to free up disk space. Unfortunately, almost every time I start the MacBook, it issues a warning, that the startup disk is almost full. Seemingly at random, checking the free disk space actually provides the 20 GB of free disk space but after a while it falls down to a few MB (!). I already tried disabling Time Machine's Local Snapshots:
sudo tmutil disablelocal
but that didn't help.
System Specs: El Capitan - 10.11.6 on a late 2013 MacBook Pro
P.S.: this is not a duplicate of Over 25 gb os Space Disappeared