Unfortunately no, not at present (10.10.1). Firstly, your MBP needs to support MST which is part of DisplayPort 1.2 - you can check your laptop's specifications as they may vary depending on which GPU option you went with when you purchased your MBP. Secondly, even if your hardware supports it (many recent MBPs do) Apple [hasn't added][1] support to OS X for this feature yet. Users who want MST on MBPs have been using bootcamp to boot to Windows which supports MST on the same hardware just fine. [1]: https://discussions.apple.com/thread/6569158 Update (10-08-2015): It would appear as though (thanks to the links of those below) that MST support has been added in 10.10.3. Yay!