I would say, the iMac is a high quality display with a free computer at a first approximation. Everything will connect as Apple went away from custom connectors along with the transition from PowerPC to Intel in 2006.
The only big issue that isn’t solvable for people that I see is some displays exist in a very bad physical size to pixel count (PPI) range and if you are doing text based work, you might hate that display on any Mac.
- What external monitor and size combinations provide best scaling on macOS?
- Which external monitor to choose for MacBook?
Everything else you can change: cables, keyboard mapping, shortcuts, your brain and scroll direction, UI changes, finding software that works in both OS ecosystems.