I started experiencing issues on MacOS Big Sur. I really only noticed on 11.5.2 since I didn't have my mouse with me on earlier versions. I discovered you need to, in System Preferences → Security & Privacy → Accessibility, enable Logi Options Daemon and Logi Options to have access. I previously only had the Daemon enabled and once I enabled Logi Options as well it started working again.
AppleTechy
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