I have a Mac Pro with a PCIe flash startup drive running MacOS Sierra. I would like to fill the 4 empty SATA HDD bays with drives and use OpenZFS to create a pool/volume.

1. Is this configuration possible?
2. What risks/issues might I face with this setup? For example, how might macOS updates affect accessing my ZFS data pool?

I'm open to using MacOS Sierra's RAID tools, but I prefer to use the ZFS file system for this due to its superior data protection and compression features.