Is it possible, using Preview (or maybe some other tool if not doable with Preview, but Preview preferably) to remove all annotations from a PDF file, without manually deleting every annotation?
In the "Tools menu", choose "show inspector". In the inspector, select "Annotations inspector".
Press CMD+A to select all annotations, then click backspace to delete them.
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It even recognises and removes annotation made by other programs! (Tested with annotations made by PDF Expert on the iPad.) – Harald Hanche-Olsen Nov 7 '17 at 10:18
