I am producing Music and when I got my macbook pro i9 16'' in 2019, I connected some USB hubs and the audio interface to these USB hubs. I also had a crackling noise in my sound output, but guilty was not a driver, nor the usb hub, nor the cable to the external audio card, but where I charged the laptop. Somehow the Charging Load influenced by unknown ways the audio output.
I still can't explain it in detail, but what helped was to separate the charging cable from any other devices, like connect charging cable on the left side and have the audio interface on the right. Also I bought a USB-C to USB-B cable (instead of the USB-C to USB hub, connecting the audio card via USB-B to USB-B) to connect the audio interface, since then noises have gone.