I followed the answer for disabling command + shift + I to open mail here: How to prevent Command-I/Command-Shift-I from opening Mac Mail when in browser?
However, this doesn't work for me. I restarted Chrome afterwards. Has there been a change recently with OSX/Chrome? Since I'm used to ctrl + shift + I on Windows, I open Mail a lot.
Also, is it safe to delete programs like Mail and Safari? Since Apple makes them so hard to delete, I'd imagine the OS might throw errors if they're deleted?