/private/var/folders is not getting empty after reboot. The folder is 200 GB! I tried safe mode too and it didn't change.
How can I thin out the folder(s)?
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It's likely that unneeded files will be cleared if you perform a Safe Boot. And then restart normally.
However, a detailed account of cleaning out /var/folders can be found here,
which seems to indicate that not everything gets deleted on a Safe boot.
But unless you are desperate for storage space or experiencing some issues, I wouldn't recommend wholesale deletion of the entire contents.
This will likely be closed as a duplicate, but I wanted to explain a couple things: When safe boot doesn’t clean these out, you have two options.
I say prepare for #2 and then try #1 and see if you can learn something in the process. Deleting the files won’t break the running OS - since the files don’t delete fully until you restart. 200 GB is not normal, something is really wrong on your Mac so erase install is the only easy cure for that.
There’s no end to the abuse some developers will heap upon private folders, so if you need to resort to deleting things here regularly, it’s generally not Apple causing the pain.