I have a 2010 MBP on Lion, and use Spotify pretty heavily - is there any way that I can have my remote control spotify, rather than it waking up iTunes every time (which would be fine but I don't have any playlists)?
You could try SpotifyIrRemote which works on Lion.
There is a plugin for spotify called Spotify Mac Remote, you can get it from the developers website here. It works great with my universal remote, should work just as great with the apple remote.
Spotify Mac Remote is a plugin for Spotify that allows you to use your Mac’s IR remote control & multi-touch gestures to Play, Pause and change tracks. The next, play/pause and previous buttons work exactly as you’d expect, the volume buttons control the system volume and holding the menu button quits Spotify – in case you want to use Frontrow.
I just made an app that lets you control Spotify with your Apple remote
(I will make the source available soon)