There's a few things you can check, but they're a little hit and miss in terms of what will work for individual users. Some of these are also troubleshooting steps to help get to the bottom of the problem (although I should state at the beginning this is quote common when you have two or more versions of Numbers installed on the same device).
Some things to try (if you haven't already):
- Shutdown your Mac, wait about 10 minutes, reboot.
- Check your Login Items to ensure you haven't got a Numbers document in the list. If so, remove it. (Go to Apple > System Preferences > Users & Groups > Login Items).
- Disconnect your Mac from all networks (including the Internet), quit Numbers, and try again.
- Boot your Mac into Safe Mode and try using Numbers. Then boot up normally and try again.
- Have Numbers 2.2 open first before trying to open Numbers files (and ensure Numbers 4.3.1 isn't running)
- Select a Numbers document in Finder and use the Get Info (commandI) option to see if you can select Numbers 2.2 from the Open with drop-down list. If you can, click on the Change All... button
If none of the above work, even temporarily, then you may have to just totally remove Numbers 4.3.1. However, this course of action is not one you will be able to use forever as Numbers has evolved significantly over time and version 2.2 won't keep working as you upgrade macOS etc.