It was not installed with Homebrew, nor does a
.wine file exist in my home directory. I don't remember when or how I installed it, but it's running and using up large amounts of CPU on my machine, and I'd like to remove it for good.
wine project has an excellent Wiki article specific to macOS. It includes how to remove
wine from your macOS system, but basically there are a few ways to uninstall
sudo port uninstall --follow-dependencies wine
brew rm wine && brew rm $(join <(brew leaves) <(brew deps wine))
sudo make uninstall rm -rf /src/wine #Remove the source rm -rf $HOME/.wine #Remove pseudo C: and registry entries rm -rf $HOME/.local #Remove desktop menu entries and icons
You can attempt any of these methods without fear that if you didn't install using that method, there won't be adverse affects to your system.