Callto/tel links inside Chrome open up for me in Facetime. How can I change the default application used for opening such links? (I'd like to set it to Skype)
Two options: 1. Do this via Facetime (Preferences > Settings > Default for calls) 2. If this doesn't work, try RCDefault App: http://www.rubicode.com/Software/RCDefaultApp/
For me, Skype was not showing in Facetime's list, but RCDefault App made it possible to add a custom app there. What I haven't yet managed to make work is that the number would get copied to Skype.
By the way, this has been answered also at https://superuser.com/questions/1132108/how-to-configure-the-default-app-to-open-tel-links-in-macos-x