I use the text to speech feature a lot. Sometimes, after I put the macbook to sleep and come back to it the feature no longer works. I would have to shutdown/restart the computer in order for the feature to work. Is there are a way to restart/enable text to speech without restarting the computer?
have you tried entering these two commands in terminal?
killall com.apple.speech.speechsynthesisd killall SpeechSynthesisServer
You can do that in activity monitor, I just like terminal better. Then wait a bit and try the shortcut again. If that doesn't work, try to change your shortcut to something else and then change it back. Also, maybe corrupted plist file?