This question is generic but for my case I have an iPhone SE with iOS 10.3.1 and a MacBook Pro running Sierra 10.12.4.
Is it possible to have my iPhone backup to both iTunes and iCloud? When I connect the phone to iTunes the backup option seems to have a radio option for one or the other.
But it seems it would be preferable to have backups in two different places, a more complete larger backup on the computer and a smaller backup to iCloud that has the settings/app list/documents.