On Youtube in safari, you can right click twice to get the PIP option.

However, I can't figure it out for amazon instant video

  • Does Amazon support PIP in Safari? I've never seen any options to use it. Do you have any info from Amazon that this is supported?
    – fsb
    Mar 19 '17 at 22:10

I don't have access to Amazon Video, so I can't test this, but try out PiPifier (Mac App Store link). It installs a Safari extension that takes any HTML 5 video and puts it in a PiP window. You can read more about PiPifier on GitHub.

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