I have a Wacom Graphire 4 CTE-640, silver. It reacts as though the pen is always down, no matter how I try to use it. The area responds, but I have to lift my hand completely for the pen to stop.
I am running Mac OS X El Capitan on a MacBook Pro.
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I have the same Graphire 4 and MacOS Mojave 10.14.5. The latest official Wacom Driver PenTablet 5.3.3-3 won't install anymore (it thinks that you have an older OS than 10.6).
SOLUTION: I tried all previous drivers until I found the most recent one that works. So the actual latest PenTablet driver that works with MacOS Mojave is the 5.3.0-3 that you can download from here: https://www.wacom.com/en-us/support/graphire-support
Hope this helps!
The Wacom Graphire 4 CTE-640 is quite an old model (over 10 years I think), so you can't really expect Wacom to continue updating drivers for newer versions of macOS.
That said, have you tried using the PenTablet 5.3.3-3 driver for Mac OS X? This is the last official driver for your model and was released to support Mac OS X Mountain Lion 10.8. If not, it may be worth giving it a go (or, if you have, removing it and re-installing it).
If installing the above driver doesn't seem to work, there's also a potential workaround that may get it to work. With the above driver installed, do as follows:
Note: I have not used the above process for your particular tablet, but I have helped others with other Wacom tablets and this has worked in some cases.