I find myself drifting away from Firefox to Safari, but the lack of NoScript is making me a little uneasy. Is there an equivalent plugin for Safari?
I'm not super familiar with NoScript, but from a quick glance at the site, I can think of two good starting points - how useful they are will depend on which features of NoScript you make use of.
ClickToPlugin is a great plugin blocker, pretty configurable, and it also has a fantastic h.264 replacement for Flash video. It substitutes h.264 video with a nice tidy player (mostly just the standard Safari player with one or two modifications) wherever it can, probably gets 80-90% of video in my experience. Makes in-browser video a lot nicer.
Ghostery is a great option if you're just aiming for privacy. It runs in every browser on every operating system, even mobile ones.