Do you have a fix for this particular scenario:
1) Two partitions boot drive, the second one formatted exFAT 2) Relocate Home directory to Partition2 using the default way:
System Preferences -> Users & Groups -> Advanced Options -> Home directory
3) Install Skype 4) At first launch Skype will freeze / not connect / CMD + Q will also freeze Skype 5) Any other app except Skype works fine
I've tried installing Skype on two different systems (El Capitan & Mavericks) with Home directory relocated to another partition and the problem persist.
If you want to experience this and hopefully find a solution you can create a small partition of a few GBs and another OS user and move its Home directory to new partition created then try to install Skype.
UPDATE: I've just learned that the issue is related to how the second partition is formatted. Skype freezes while partition2 is formatted as ExFAT but if I format it as Mac OS Extended, Skype works fine.
I am ready to any kind of solution but is very very relevant for my that Desktop + Documents + Downloads folders to remain on partition2 formatted as ExFAT.