Since updating to OSX 10.11.3, I have found Photoshop CS6 will not load, as well as several other programs. Others include Hugin, possibly Dragon Dictate 5 (not resolved or confirmed yet re VP updating), Bamboo digital tablet, and a few others.
Concentrating on Photoshop CS6, for me following upgrading to OSX 10.11.3 it begins to load then freezes. A web search (several done over a few months) seems to suggest for others there is no issue, yet for others there is, and for some few if any of the CS6 suite is working. Adobe no longer offers support for CS6. Apple is silent.
I am left confused if there are few or many that find Photoshop CS6 working fine on OSX 10.11.x. If here are many, perhaps a recent replacement of the motherboard, CPU/GPU is the real issue, not OSX 10.11.x in my case.
I understand OSX 10.11 relocated some system files as part of improved security, so it could be the issue. Others posts on other sites seemed originally to confirm this.
This article seems to outline these changes best: Article Security Changes OSX 10.11.x
Lost and confused.