Is it possible to install InkScape without XQuartz?
I did install it already and it's working but I feel like it's not that native (e.g. the menu doesn't appear on the top pannel but until the title bar).
How to install InkScape without XQuartz?
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Not officially possible, yet—the Inkscape developers will have to remove the XQuartz dependency by switching to the native Gtk and Glib libraries for OS X, just like the GIMP team did a few years ago.
This work has been in progress for a couple of years on a separate Inkscape branch, but there is no official release yet. However, you can download the latest DMG here (currently based on Inkscape 0.91) both for GTK2 and GTK3 (experimental), at your own risk—expect bugs and crashes.
Inkscape 1.0 will include first class support for Mac OS X with no need for XQuartz.
If you are willing to try alpha software, you can download a dmg right now from https://inkscape.org/release/inkscape-1.0/?latest=1 by clicking on the Mac OS X and then choose Apple's Mac OS X Desktop.
Or click, A build from the CI build Alpha Tarball to build from the command line.