I would imagine using a Disk Utility partition, but I didn't see the option in Disk Utility to split a larger partition into several.
How can it be done on a Mac?
I am doing this because I would like to Mail Drop the file.
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OS X includes a command line tool called
man split for all the details.
You can call
split using the Terminal.app and the command:
split -b 5000m MYBIGFILE
To combine it again, have the receiver store all parts in a dedicated folder, open Terminal there and run
cat x?? > MYBIGFILE
(This assumes that you used the default output names when running