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I have a Mac mini late 2012 with 4 GB (2 x 2 GB) RAM. I bought another 8 GB RAM module and installed it in the Mac. Should I leave the 8 GB module alone or should I install one of the two 2 GB modules in the vacant RAM slot?

Will there be any issue if there are different RAM modules in the slots (8 GB + 2 GB)?

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I have an early 2011 MacBook Pro, formerly with 4GB of RAM. A few months ago, I bought an 8GB stick and made the exact setup you're describing. With the exception of one issue that lasted a few minutes one day (and that I have no proof was even caused by the RAM setup), it's been working perfectly ever since I did the upgrade.

So yeah, you should be fine. Source: My own experience doing exactly the same thing.

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If the two different sized RAM modules have the same specifications (e.g. latency), you shouldn't have any issues.

The advantages - more memory - outweigh the disadvantages of different sized modules - no interleaving memory.

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    and it works with my experience a 2012 mini with an 8G and 2G RAM – mmmmmm Sep 19 '15 at 15:23
  • This is my answer always since 2013. Add bigger modules to keep a slot free if you don’t know how much RAM is enough or make sure you’re ok selling or throwing away if you insist on installing matching pairs. – bmike♦ May 11 '19 at 17:31

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