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I read that on previous versions of OS X it was possible via hwprefs but I didn't figure out how to use it on 10.10.* (looks like it was removed). I need to disable HyperThreading for Wineskin.

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    May I know why you need to disable it ? (or why Wineskin needs to disable it). Also which mac do you have ?
    – Matthieu Riegler
    Jul 15, 2015 at 13:38
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    Some programs don't work properly with HyperThreading link. Wineskin has a one check box in settings: "Limit to 1 CPU core (set at an OS level for all apps. Only work if you have hwprefs installed)" I have MacBook Pro (Retina, 13, Late 2012) Core i5, Intel HD 4000
    – lebed2045
    Jul 15, 2015 at 18:08

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Indeed there is a solution, but you have to have Xcode installed.

Search for "Instruments" with Spotlight (cmd+space), open the application and go to the preferences (cmd+,). Select the "CPUs" tab and untick "Hardware Multi-Threading".

However, after restarting your Mac it will be enabled again.

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    Not only after restart but sleep as well.
    – poige
    Nov 7, 2018 at 19:10

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