According to the debug logs this is related to a problem with loading /System/Library/Extensions/cpfw.kext
[ 66 2571][19 Oct 10:46:31][TR_FIREWALL] CFirewallWrapper::EnforcePolicy: firewall not initialized, calling init
[ 66 2571][19 Oct 10:46:31][TR_FIREWALL] CFirewallWrapper::Init: entering...
[ 66 2571][19 Oct 10:46:31][TR_FIREWALL] CFirewallWrapper::Init: MACOS init firewall, g_kextPath=/System/Library/Extensions/cpfw.kext
[ 66 2571][19 Oct 10:46:32][TR_FIREWALL] CFirewallWrapper::Init: CpfwLoadKext returned cpfwlib_kextload_failed
[ 66 2571][19 Oct 10:46:32][TR_FIREWALL] CFirewallWrapper::Init: CpfwLoadKext Failed with error cpfwlib_kextload_failed
[ 66 2571][19 Oct 10:46:32][TR_FIREWALL] CFirewallWrapper::Init: CpfwDiagnoseLoadKext return:
Can't stat 4/System/Library/Extensions/cpfw.kext - No such file or directory.
Deleting the site and re-creating it does not fix this problem.
Uninstalling and re-installing the Check Point Endpoint Security client (version E75.01) worked for me too and I am using a static IP (not DHCP) on my mac mini.
Note about uninstalling the Endpoint Security client E75.x and newer: Open the original DMG package you used to install the client and launch the Uninstaller shown. If you get an error message about your security settings not allowing non-appstore apps or untrusted applications from launching, hold down the Control key and then click on the Uninstaller. Selecting Open at this point will allow the Uninstaller to run.
I did confirm the uninstall removed and the reinstall did create a new /System/Library/Extensions/cpfw.kext file. I did not have to reboot but note I did shutdown the client before running the uninstaller.
However this may be a temporary fix as there is a Checkpoint Forum entry about another person who has also encountered this problem and has fixed it by uninstalling and installing but on a reboot the problem came back for them. That person tried versions E80.41 and E80.42.
See https://forums.checkpoint.com/forums/thread.jspa?threadID=21491&tstart=0
Another Check Point Mac VPN Yosemite thread is reporting similar issues where some claim their client still works after a reboot but others, including the author of the above thread, who continue to see the problem return after a reboot: https://forums.checkpoint.com/forums/thread.jspa?threadID=21181&tstart=0