I have a Macbook Pro (Retina, 13", Late 2013) running Lion 10.9.4, that I use with an external thunderbolt display, a bluetooth trackpad, and a USB keyboard -- both of which are connected through the thunderbolt display.
Often (but not every time), when I disconnect from the thunderbolt and go elsewhere, I find that the physical keyboard & trackpad on the MBP become totally unresponsive. I have only found two fixes for this, so far:
- Repeatedly reconnect/disconnect the thunderbolt display & retry the physical keyboard & trackpad until they work again -- sometimes this happens on the first try, other times it takes 10, 20, even 30 or more attempts.
- Hard reboot via the power button -- which is ironically the only key on the physical keyboard that does anything at all.
I found mention of a similar problem (without a thunderbolt display involved) that suggested closing the macbook for 30+ seconds, but this does not fix my issue.
This appears to be a general USB issue, as I've now noticed the same thing occasionally happening when I connect my phone or other devices via USB. Still no clue as to the cause or how to fix it.