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I want to change option in System Preferences "Scroll direction: natural" every time I plugin mouse to my MacBook.

And switch back when mouse is disconnected.

This should happen automatically. How it's possible? Automator or applescript?

1

You can use Keyboard Maestro:

Repeat script with 'is disconnected'.
You may need to change the USB device name.
AppleScript from shell script: Toggle Natural scrolling from command line with reload

  • Thank you, but Keyboard Maestro is not free software. – Stmol Jul 14 '14 at 17:56

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