4 Basic Spotlight Shortcuts
These are the most basic shortcuts to use Spotlight:
Open Spotlight menu – Command+Space
Open Spotlight in the Finder – Command+Option+Space
Clear Spotlight search box – Escape
Close Spotlight menu – Escape twice
7 Spotlight Usage & Navigation Keyboard Shortcuts
These shortcuts are for interacting and navigating within Spotlight search results:
Open first search item – Return
Navigate search results – Arrow Up and Arrow Down
Open to location of first search item in Finder – Command+Return
Get Info on search item – Command+I
Show Quick Look Preview of Spotlight results – Command key or hover with the Mouse cursor (OS X 10.7 and later only)
Show path/location of search result – Command+Option while hovering over search result
Jump categories in search results – Command+Arrow Up or Command+Arrow Down
Take a look at this for more details.