I am now using Vinegar.app and it works very well.
What it basically does is that it queries the video as though it was requested onto an iPad with at least 1080p resolution, and probably send a refresh request immediately once the video hyperlink was started to load. (This prevents the playing of video ads on iOS and iPadOS, but was not made available for macOS by YouTube)
Pros
Additional advantages other than 0 video ads include that
- one no longer has to confirm "[they are] there", video playback won’t pause on its own;
- videos won't jump to any random YouTube-choice video;
- the "replay" button with same label not only is available after, but throughout playback too;
- there is a working "loop" button which keeps the video playing if activated;
- videos can be popped out as a floating window to play outside of Safari altogether;
- video resolution may be preset to "best [available]"; and
- left and right arrows to jump 15 seconds never screw up by increasing or decreasing volume (volume is controlled by the up and down arrow if you hover over the volume virtual button).
Cons
Three shortcomings of this solution are that
- the next song and previous song buttons in playlists are not available if in use;
- no thumbnail preview of the video when hovering the pointer over the video timeline; and
- the "best" resolution option may occasionally fail (exhibited this issue when the resolution was 1st changed).