There are some software updates I'm not interested in, either because I don't use the applications involved or because I don't care.
I uncheck them and click Not now
The annoying part is that they keep popping up every time there's a new update.
Can't you uncheck them forever so the updates-to-ignore list doesn't keep growing?

For example, I couldn't care less about stability when sending slideshows from iPhoto'11 to iDVD, something I don't do anyway.