Combination Cmd+Opt+some key is pretty common in OS X. For example "cut": Cmd+C Cmd+Opt+V.
I'm struggling to press it with one hand. It's hard. Things goes insane if combination also includes Shift ("Save for Web" in Photoshop - Cmd+Opt+Shift+S).
It is easier to press "equivalent" Ctrl + Alt on Windows which placed like Ctrl+Command on Mac.
First of all I was trying to avoid Cmd+Opt in any sofware I used. But it looks like, it's the "OS X way" and there always be the software containing shortcuts with this combination.
How do live with this? How to make it less painful?