I moved my /Users directory to a separate disk/partition (to get it off my SSD boot disk) as per this post. However, some things (like double-clicks of .html files to be viewed in a an Opera browser) ...
I've got a mid-2010 MBP running OS X 10.8.4. I've got a Sandisk SSD as my boot drive in my Super Bay and a 1.5TB hard disk in my HD bay. (I realize I could get better SSD performance if I swapped ...