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I have tried command that I found and it works for second and after that second client closes.

open -na /Applications/

Other command that I tryied with the same resul.

/Applications/ &
[2] 27307
[1]   Exit 126                /Applications/

What command I must use to have multiple Mumble instances open?

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Are you sure that Mumble even supports running with several instances at once? – patrix Nov 4 '12 at 15:56
On Windows - I'm sure that it is possible.… – iber Nov 4 '12 at 20:20
There it also says you need to specify -m when starting the first client, did you try that (/Applications/ -m) – patrix Nov 4 '12 at 20:59
It worked but is not possible to connect as a two diffrent users. – iber Nov 5 '12 at 11:14
Then you are probably better off asking at directly – patrix Nov 5 '12 at 12:19

What you and future searchers are looking for is this:

open -n /Applications/ --args -m

This is valid as of 11/04/14 on OS X 10.10/Darwin 14.0.0 (Yosemite)

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