I appreciate that Notification Center is in its infancy but I was wondering if anyone had any idea how to intercept clicks on the "bubbles" that are generated and run your own actions.
Specifically, I'd like to be able to launch a local Twitter client rather than the website when clicking on a tweet notification?
.plists, etc to modify your system as an end user are very much on-topic. If you're asking how to do this as part of writing a program, you're in the wrong place, but if you're asking, as an end user, how to hack your system so NC launches your favorite client instead of the website, you're not off-topic (although I'm doubtful there will be an easy answer to your question) – Daniel Lawson♦ Aug 9 '12 at 12:52