Try this AppleScript:
tell application "Finder"
set workFolder to (POSIX file "/Users/yourname/Documents/Work") as alias
For some reason, the tilde doesn't work in the path, so you have to enter your home folder. Since you want to assign that to a shortcut, download FastScripts which enables you to assign shortcuts to AppleScripts.
Hope this helps!
You can alternatively make an Automator service to run the Applescript.
- Open Automator and select Service
- On the left-side menu, select Utilities.
- In Utilities, drag and drop the "Run Applescript" action into your workflow
- Copy the applescript above into the "Run Applescript" action