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Ever since upgrading to Mountain Lion I have had endless problems with Apps and firefox. My current issue is that I am unable to download files using firefox ever since the update. I get a messagebox saying the error

/Users/username/Downloads could not be saved, because an unknown error occurred.

Try saving to a different location.

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NP. Have you tried changing the default download location? – ephsmith Aug 1 '12 at 19:48
up vote 0 down vote accepted

After changing the download location, I proceeded to restart my computer and it appears to be working now.

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This may suggest permissions problem with the Downloads folder. Try to verify and fix permissions (Utilities, then Disk Utility) – lupincho Aug 1 '12 at 19:52
I've seen similar errors when the Profile folder inside ~/Library/Application Support/Firefox/Profiles has incorrect permissions. – da4 Aug 1 '12 at 19:56
@lupincho that found lots of incorrect permissions, repairing now. – h00j Aug 1 '12 at 20:01

Once again, the problems are not with permissions. In Firefox's preferences, on the general tab, Set Firefox to "Always ask me where to save files" under Downloads. Files will download fine, to the Downloads folder or anywhere else.

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