Is there any way to have different "little snitch" rules set for different networking profiles ? like for HOME one rule list for WORK another etc ...
Little Snitch will tell you and allow you to do the following:
Unfortunately what it does not allow you to do is filter or create rules based on the "Location" or the current connection name as defined in OS X Network preferences (with the exception of "Local Network")
Other Firewall Software may allow you to do this, but this is a limitation of Little Snitch.
Littel Snitch 3 is now in preview mode, one among the new features is "Profiles" defined as follows: