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When annotating a PDF in Preview I regularly highlight text then add a note to that highlight. This is a frustrating process as I can do the first bit with a keyboard shortcut, but must then right-click the highlight to add a note to it. I want to be able to do all this with a single key combination. Any ideas how to make this possible?

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Preview is sadly not scriptable, so any solution will have to employ GUI scripting, which is inherently going to be clunkier. –  Daniel May 27 '12 at 20:10
Have you looked at Skim.app? –  user588 May 27 '12 at 22:28

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