We suggest nessMediaCenter (http://www.nessmediacenter.com).
It is like FrontRow designed to use the Mac system features - that way it is small (8 MB) and needs less system power.
The hight contrast (white on black) and large font size allows it to recognize the content better than in other media centers. Background / foreground color and font size (aka how many entries are shown) can be setup in the preferences.
The media center offers internet content, iPhoto & iTunes media, Miro video podcasts and local media (picture / movie folder and volumes).
The local media can be accessed without adding it to a separate library - local media is organized as the Finder's folder structure.
For DVDs a preview will be searched automatically - thru "Movie Info" a preview and description can be set for DVDs and videos / movies.
The "Movie Info" also allows it to save all movie informations as HTML page to share these informations with your friends.
Supported media: pictures, videos / movies, PDFs, DVDs, EyeTV movies.
By installing the QuickTime extension "Perian", all common video formats are playable (AVI, DivX, MKV etc.).
Protected iTunes media (DRM) will be started in iTunes, EyeTV movies in EyeTV or VLC (if EyeTV is not available).
It can be controlled by Apple remote control, "NV Remote App" for iOS (http://itunes.apple.com/en/app/nv-remote/id389343735) or keyboard.
With "NV Remote App" and the iTunes control of the media center, the music can be controlled within the local WLAN. In landscape mode the app will show the current selection - very helpful if one is sitting e.g. in the kitchen and want to change the playlist.
nessMediaCenter can be used as demo for 30 minutes after each launch. The full versions costs 9.50 Euro.
(This is a promotion - my company "FINESS UG" is selling nessMediaCenter.)