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I have tried a number of times to make VLC Media player the default for MP3 and MP4. I open a file and tick the "Always open with" checkbox, but they still open with iTunes and QuickTime by default respectively. Does anyone know how to fix this?

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up vote 11 down vote accepted

Try one of these 2 solutions I hope they'll solve your problem:

1- use "Default Apps" for change every default application.

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2- From the Finder, select a MP-4 file, open the Info panel (FileGet Info or I), select your preferred application and then click Change All…

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So "Always open with" only applies to one file? – Casebash Nov 13 '10 at 8:20
@Casebash, Yes if you "Always open with" it just work for the specific file(s). – Am1rr3zA Nov 13 '10 at 8:33

You can use utility like Magic Launch to do that.

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