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I have a radio app that I listen to all the time. Then I want to visit a website which has sound (or a game).

Is there a way to mute sound from an application?

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Finally something that works like in windows

Screenshot

Volume Mixer for Mac lives in your menu bar. With simple features like muting apps by double clicking and detaching an app from the master volume by right clicking, Volume Mixer is easy to learn and simple to use.

http://www.volumemixer-app.com/

Sadly not for free but it seems to have been harder work than you think, so support the devs!

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I sadly muss add this note: It's not that stable it should be. But it's worth a try! – CodeBrauer Mar 15 at 9:35

Also take a look at Hear, a systemwide Audio program that does mixing, EQ, etc.

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Audio Hijack Pro allows you to mute sound from any application. It is actually for recording an application, but you can mute applications as well. You can use the demo to just mute the sound. You shouldn't have to purchase a license.
Here's a screenshot. As you can see, the controls are at the top. Audio Hijack Pro

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I suggest you use jackosx, which is free.

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Perhaps I'm missing something here (emphasis mine):

Is there a way to mute sound from an application?

If you are looking to simply mute quickly across applications, couldn't you just use the 🔈 key (I know, the emoji is not an accurate representation of the key, but it's the thought that counts, right?)

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