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I have a radio app that I listen to all the time. Then I want to visit a website which has sound (or a game).

Is there a way to mute sound from an application?

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4 Answers 4

Audio Hijack Pro allows you to mute sound from any application. It is actually for recording an application, but you can mute applications as well. You can use the demo to just mute the sound. You shouldn't have to purchase a license.
Here's a screenshot. As you can see, the controls are at the top. Audio Hijack Pro

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Also take a look at Hear, a systemwide Audio program that does mixing, EQ, etc.

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I suggest you use jackosx.

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Hear from Prosoft Engineering is a good option for independent sound control as well as improving the sound quality and customizing the sound based on your own preferences. They also offer a free 30 day demo.

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How does this address the muting sound from one app but letting sound from others play? –  bmike Mar 6 at 21:38

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