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I have a radio app that I listen to all the time. Then I want to visit a website which has sound (or a game).

Is there a way to mute sound from an application?

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3 Answers 3

Also take a look at Hear, a systemwide Audio program that does mixing, EQ, etc.

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Audio Hijack Pro allows you to mute sound from any application. It is actually for recording an application, but you can mute applications as well. You can use the demo to just mute the sound. You shouldn't have to purchase a license.
Here's a screenshot. As you can see, the controls are at the top. Audio Hijack Pro

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I suggest you use jackosx, which is free.

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