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I can't think of any reason why Command ⌘ + Enter ↩ would not send a mail draft, instead of the current shortcut, which is Command ⌘ + Shift ⇧ + D Is there a way to change this?

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up vote 8 down vote accepted

You can look at this answer and apply accordingly to your case.

TL;DR version:

system preferences keyboard shortcut

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I tried to use the System Preferences, Keyboard Shortcuts tab to define Command+Return to send a mail. But the effect was that Command+Shift+Return sends mail.

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Did you solve this? I have the same problem. – Daniel Serodio Sep 26 '14 at 13:33
Daniel Serodio, I am using MailMate now, which kind of solves it, but it's not what you had in mind... – hibbelig Sep 27 '14 at 20:18

I found a solution in Mathias's dotfiles. In a Terminal window, type:

defaults write NSUserKeyEquivalents -dict-add "Send" "@\U21a9"

Then restart

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