I've exactly the same problem after updating to 10.9.3 yesterday but with slightly different folders...
Users folder same problem as with yours
Users/Shared same problem as with yours
and
Applications/Safari.app/Contents/Resources/Safari.help/Contents/Resources/index.html
should be: Irwxr-xr-x
is: -rwxr-xr-x
Doesn't matter what I'll try, after the next reboot the problem say's hello again.
Well I've not the chance to test it yet but you might wanna give the following a try:
Start your computer with Alt + CMD + P + R in order to a PRAM reset.
Start your computer with CMD + R for recovery partition boot Launch Disc Utility and repair the permissions. Quit Disk Utility and open the Terminal (Utilities -->> Terminal) and type:
cd /Volumes/Macintosh\ HD (or the name of your partition)
chmod 755 Users
chmod 755 Users/Shared
chflags nohidden Users
chflags nohidden Users/Shared
Restart, normally everything should be back to normal