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Command+Left and Command+Right are both incredibly useful key combinations. By contrast, Command+Up and Command+Down are incredibly irritating. I almost never actually need a shortcut to the top of the document. 99 times out of 100, when I press Command+Up or Command+Down, it's by accident, usually when meaning to press one of the useful combinations. Is there any way to switch those two off?

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You can use KeyRemap4MacBook with a private.xml such as this:

<?xml version="1.0"?>
    <name>Disable ⌘↑ and ⌘↓</name>
      KeyCode::CURSOR_UP, VK_COMMAND | ModifierFlag::NONE,
      KeyCode::CURSOR_DOWN, VK_COMMAND | ModifierFlag::NONE,

Just CURSOR_UP, VK_COMMAND without | ModifierFlag::NONE would also disable for example option-command-up.

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