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My goal is to select a file in Finder and get to the "open with" menu without having to leave the keyboard.

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you can find some note here:… – Am1rr3zA Mar 27 '11 at 23:03

You can use Ctrl+F2 to move the focus to the menu bar and then use the arrows to go to the Open With menu item.

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Not without 3rd party. Check out BetterTouchTool.

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I've been using a keyboard shortcut to simulate 'ctrl+click', the problem is that only works if my mouse is on top of the file – Penang Mar 28 '11 at 1:17

I second the Quicksilver answer in the superuser thread referred to above — If you're a keyboard person you have to have this (or similar apps like Launchbar or Alfred).

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